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1

Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies

Tran, John C., Tran, Daniel, Hilderbrand, Amy, Andersen, Nisana, Huang, Tao, Reif, Karin, Hotzel, Isidro, Stefanich, Eric G., Liu, Yichin, Wang, Jianyong

Journal:

Analytical Chemistry

Year:

2016

Language:

english

File:

PDF, 573 KB

english, 2016

2

High-throughput assays for sirtuin enzymes: A microfluidic mobility shift assay and a bioluminescence assay

Yichin Liu, Raphaele Gerber, John Wu, Trace Tsuruda, John D. McCarter

Journal:

Analytical Biochemistry

Year:

2008

Language:

english

File:

PDF, 953 KB

english, 2008

3

Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

Yichin Liu, Hilal A. Lashuel, Sungwoon Choi, Xuechao Xing, April Case, Jake Ni, Li-An Yeh, Gregory D. Cuny, Ross L. Stein, Peter T. Lansbury Jr.

Journal:

Chemistry & Biology

Year:

2003

Language:

english

File:

PDF, 720 KB

english, 2003

4

Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling

Chen, Huifen, Chan, Bryan K., Drummond, Jason, Estrada, Anthony A., Gunzner-Toste, Janet, Liu, Xingrong, Liu, Yichin, Moffat, John, Shore, Daniel, Sweeney, Zachary K., Tran, Thuy, Wang, Shumei, Zhao,

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 3.16 MB

english, 2012

5

Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors

David Meininger, Leeanne Zalameda, Yichin Liu, Lara P. Stepan, Luis Borges, John D. McCarter, Claire L. Sutherland

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2011

Language:

english

File:

PDF, 1.43 MB

english, 2011

6

The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

Yichin Liu, Lara Fallon, Hilal A. Lashuel, Zhihua Liu, Peter T. Lansbury Jr.

Journal:

Year:

2002

Language:

english

File:

PDF, 453 KB

english, 2002

7

Discovery of Acetyl-Coenzyme A Carboxylase 2 Inhibitors: Comparison of a Fluorescence Intensity-Based Phosphate Assay and a Fluorescence Polarization-Based ADP Assay for High-Throughput Screening

Liu, Yichin, Zalameda, Leeanne, Kim, Ki Won, Wang, Minghan, McCarter, John D.

Journal:

Assay and Drug Development Technologies

Year:

2007

Language:

english

File:

PDF, 3.90 MB

english, 2007

8

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

Fauber, Benjamin P., Dragovich, Peter S., Chen, Jinhua, Corson, Laura B., Ding, Charles Z., Eigenbrot, Charles, Giannetti, Anthony M., Hunsaker, Thomas, Labadie, Sharada, Liu, Yichin, Liu, Yingchun, M

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.84 MB

english, 2013

9

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

Dragovich, Peter S., Fauber, Benjamin P., Corson, Laura B., Ding, Charles Z., Eigenbrot, Charles, Ge, HongXiu, Giannetti, Anthony M., Hunsaker, Thomas, Labadie, Sharada, Liu, Yichin, Malek, Shiva, Pan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.89 MB

english, 2013

10

Label-free high-throughput assays to screen and characterize novel lactate dehydrogenase inhibitors

VanderPorten, Erica, Frick, Lauren, Turincio, Rebecca, Thana, Peter, LaMarr, William, Liu, Yichin

Journal:

Analytical Biochemistry

Year:

2013

Language:

english

File:

PDF, 2.07 MB

english, 2013

11

Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors

Pastor, Richard M., Burch, Jason D., Magnuson, Steven, Ortwine, Daniel F., Chen, Yuan, De La Torre, Kelly, Ding, Xiao, Eigenbrot, Charles, Johnson, Adam, Liimatta, Marya, Liu, Yichin, Shia, Steven, Wa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.73 MB

english, 2014

12

Allosteric inhibition of BACE1 by an exosite-binding antibody

Wang, Weiru, Liu, Yichin, Lazarus, Robert A

Journal:

Current Opinion in Structural Biology

Year:

2013

Language:

english

File:

PDF, 2.10 MB

english, 2013

13

Electrostatic Mechanism for DNA Bending by bZIP Proteins †

Paolella, David N., Liu, Yichin, Fabian, Miles A., Schepartz, Alanna

Journal:

Year:

1997

Language:

english

File:

PDF, 245 KB

english, 1997

14

Differential Effects of Divalent Manganese and Magnesium on the Kinase Activity of Leucine-Rich Repeat Kinase 2 (LRRK2)

Lovitt, Brian, VanderPorten, Erica C., Sheng, Zejuan, Zhu, Haitao, Drummond, Jake, Liu, Yichin

Journal:

Year:

2010

Language:

english

File:

PDF, 1.84 MB

english, 2010

15

Kinetic Preference for Oriented DNA Binding by the Yeast TATA-Binding Protein TBP

Liu, Yichin, Schepartz, Alanna

Journal:

Year:

2001

Language:

english

File:

PDF, 610 KB

english, 2001

16

Cover Picture: Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase (ChemBioChem 8/2014)

Oh, Angela, Ho, Yen-Ching, Zak, Mark, Liu, Yongbo, Chen, Xukun, Yuen, Po-wai, Zheng, Xiaozhang, Liu, Yichin, Dragovich, Peter S., Wang, Weiru

Journal:

Year:

2014

File:

PDF, 641 KB

2014

17

Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase

Oh, Angela, Ho, Yen-Ching, Zak, Mark, Liu, Yongbo, Chen, Xukun, Yuen, Po-wai, Zheng, Xiaozhang, Liu, Yichin, Dragovich, Peter S., Wang, Weiru

Journal:

Year:

2014

Language:

english

File:

PDF, 2.06 MB

english, 2014

18

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N -(1 H -Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)

Patel, Snahel, Harris, Seth F., Gibbons, Paul, Deshmukh, Gauri, Gustafson, Amy, Kellar, Terry, Lin, Han, Liu, Xingrong, Liu, Yanzhou, Liu, Yichin, Ma, Changyou, Scearce-Levie, Kimberly, Ghosh, Arundha

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 4.24 MB

english, 2015

19

Identification of Small-Molecule Noncovalent Binders Utilizing SAMDI Technology

VanderPorten, Erica C., Scholle, Michael D., Sherrill, John, Tran, John C., Liu, Yichin

Journal:

Year:

2017

Language:

english

File:

PDF, 788 KB

english, 2017

20

Cathepsin B is dispensable for cellular processing of cathepsin B-cleavable antibody-drug conjugates

Caculitan, Niña G., dela Cruz Chuh, Josefa, Ma, Yong, Zhang, Donglu, Kozak, Katherine R, Liu, Yichin, Pillow, Thomas H., Sadowsky, Jack, Cheung, Tommy K, Phung, Qui, Haley, Benjamin, Lee, Byoung-Chul,

Journal:

Cancer Research

Year:

2017

Language:

english

File:

PDF, 2.91 MB

english, 2017

21

Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity

Wei, Binqing, Gunzner-Toste, Janet, Yao, Hui, Wang, Tao, Wang, Jing, Xu, Zijin, Chen, Jinhua, Wai, John, Nonomiya, Jim, Tsai, Siao Ping, Cruz-Chuh, Josefa dela, Kozak, Katherine Ruth, Liu, Yichin, Yu,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.77 MB

english, 2017

22

Automated On-tip Affinity Capture Coupled with Mass Spectrometry to Characterize Intact Antibody-Drug Conjugates from Blood

Li, Ke Sherry, Chu, Phillip Y., Fourie-O’Donohue, Aimee, Srikumar, Neha, Kozak, Katherine R., Liu, Yichin, Tran, John C.

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2018

Language:

english

File:

PDF, 1.10 MB

english, 2018

23

Quantitative determination of protein-ligand affinity by size exclusion chromatography directly coupled to high-resolution native mass spectrometry

Ren, Chengfeng, Bailey, Aaron Oakley, VanderPorten, Erica C, Oh, Angela, Phung, Wilson, Mulvihill, Melinda M, Harris, Seth F., Liu, Yichin, Han, Guanghui, Sandoval, Wendy

Journal:

Analytical Chemistry

Year:

2018

Language:

english

File:

PDF, 1.34 MB

english, 2018

24

Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody- drug conjugates

Zhang, Donglu, Fourie-O'Donohue, Aimee, Dragovich, Peter S, Pillow, Thomas H, Sadowsky, Jack D, Kozak, Katherine R, Cass, Robert T, Liu, Liling, Deng, Yuzhong, Liu, Yichin, Hop, Cornelis ECA, Khojaste

Journal:

Drug Metabolism and Disposition

Year:

2019

Language:

english

File:

PDF, 808 KB

english, 2019

25

A Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry

Park, Hae-Min, Winton, Valerie J., Drader, Jared J., Manalili Wheeler, Sheri, Lazar, Greg A., Kelleher, Neil L, Liu, Yichin, Tran, John C., Compton, Philip D.

Journal:

Analytical Chemistry

Year:

2019

Language:

english

File:

PDF, 769 KB

english, 2019

26

A Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry

Park, Hae-Min, Winton, Valerie J., Drader, Jared J., Manalili Wheeler, Sheri, Lazar, Greg A., Kelleher, Neil L, Liu, Yichin, Tran, John C., Compton, Philip D.

Journal:

Analytical Chemistry

Year:

2019

File:

PDF, 769 KB

2019

27

High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

Sawyer, William S., Srikumar, Neha, Carver, Joseph, Chu, Phillip Y., Shen, Amy, Xu, Ankai, Williams, Ambrose J., Spiess, Christoph, Wu, Cong, Liu, Yichin, Tran, John C.

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

File:

PDF, 1.09 MB

2020

28

Characterizing and Quantitating Therapeutic Tethered Multimeric Antibody Degradation Using Affinity Capture Mass Spectrometry

Li, Wenjing, Srikumar, Neha, Forrest, William F., Ellerman, Diego, Gu, Chen, Tchelepi, Robert, Lazar, Greg A., Liu, Yichin, Tran, John C.

Journal:

Analytical Chemistry

Year:

2020

File:

PDF, 1.08 MB

2020